Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Rilpivirine. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1 infection. Structurally, rilpivirine is a diarylpyrimidine derivative. It functions by inhibiting the reverse transcriptase enzyme of the human immunodeficiency virus (HIV), thereby impeding the replication of the virus within human cells. Rilpivirine is often prescribed as part of combination antiretroviral therapy (ART) to suppress viral replication and manage HIV infection. Its use is typically reserved for individuals with no prior history of antiretroviral treatment and with low viral loads.
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