Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Riociguat. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Riociguat is a medication used for the treatment of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Chemically, it is a soluble guanylate cyclase (sGC) stimulator. Riociguat works by increasing the sensitivity of sGC to nitric oxide, leading to the production of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels help relax the pulmonary arteries and improve blood flow, reducing the strain on the heart and alleviating symptoms associated with pulmonary hypertension.
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