Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Rolapitant. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Rolapitant is a medication used to prevent nausea and vomiting associated with chemotherapy. Structurally, it is a selective neurokinin-1 (NK1) receptor antagonist. NK1 receptors play a role in mediating signals that lead to nausea and vomiting. By blocking these receptors, rolapitant helps to inhibit the action of substance P, a neurotransmitter involved in these processes. Rolapitant is typically administered orally as a single dose before chemotherapy, providing an extended duration of action. It is often used in combination with other antiemetic medications to offer comprehensive prevention of chemotherapy-induced nausea and vomiting.
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