Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Selexipag. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds.
Selexipag is a medication used in the treatment of pulmonary arterial hypertension (PAH). Chemically, it is an oral prostacyclin receptor agonist. Selexipag works by activating the prostacyclin receptor, leading to vasodilation in the pulmonary arteries and inhibiting the proliferation of smooth muscle cells. This helps reduce pulmonary vascular resistance and improve exercise capacity in individuals with PAH. Selexipag is typically administered orally in tablet form and is part of the therapeutic arsenal for managing pulmonary arterial hypertension. The use of selexipag is supervised by healthcare professionals, and careful monitoring is essential due to potential side effects and the need for dose adjustments to achieve optimal therapeutic outcomes.
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