Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Tafenoquine. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Tafenoquine is an antimalarial medication used for the prevention of relapse in Plasmodium vivax malaria and for the prophylaxis of malaria caused by Plasmodium falciparum. Its chemical structure belongs to the 8-aminoquinoline class. Tafenoquine works by disrupting the lifecycle of the malaria parasite in the liver, preventing relapses of P. vivax malaria. It is typically administered as a single dose after the treatment of the acute infection. Tafenoquines long duration of action and effectiveness against both P. vivax and P. falciparum make it a valuable tool in malaria prevention, particularly in regions where these malaria species are prevalent. However, its use is subject to considerations such as contraindications in individuals with certain medical conditions or glucose-6-phosphate dehydrogenase (G6PD) deficiency.
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