Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Colistin. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Colistin, a polymyxin antibiotic, is used to treat severe bacterial infections, particularly those caused by multidrug-resistant Gram-negative bacteria. Structurally, it is a polypeptide antibiotic. Colistin disrupts bacterial cell membranes by binding to lipopolysaccharides, resulting in increased permeability and eventual cell death. Administered intravenously or through inhalation, colistin is often considered a last-resort treatment due to its potential for nephrotoxicity and neurotoxicity. Its role has become more critical in the face of antibiotic-resistant strains, where colistin remains effective against certain bacteria that are resistant to other antibiotics.
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