Nitrosamines can be formed through various chemical processes, including the reaction between nitrites and secondary amines in certain conditions. It is a N-Nitroso of secondary amine present in Pazopanib. Nitrosamines are part of a broader class of compounds known as N-nitroso compounds. Pazopanib is a tyrosine kinase inhibitor used in the treatment of certain types of cancer, particularly advanced renal cell carcinoma (kidney cancer) and soft tissue sarcoma. As a targeted therapy, pazopanib interferes with the signaling pathways involved in the growth and spread of cancer cells by inhibiting specific tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and c-kit. By blocking these pathways, pazopanib helps impede angiogenesis (the formation of new blood vessels) and suppresses the tumors ability to grow and metastasize. It is administered orally and is part of a broader treatment strategy for individuals with specific types of advanced or metastatic cancers.
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